luciaMexico.jpg

 

Dr. Lucia Battistini

 

BOSS Group

(BioOrganicSynthesiS Group)

 

UNIVERSITÀ DEGLI STUDI DI PARMA

DIPARTIMENTO FARMACEUTICO

Viale G. P. Usberti 27A

I-43100 Parma (Italy)

Tel.: +39-0521-906040

Fax: +39-0521-905006

e-mail: lucia.battistini@unipr.it

 

 

Curriculum

v      Lucia Battistini obtained her Laurea degree in Pharmaceutical Chemistry and Technology from the University of Parma in 1995, performing research on the synthesis of non natural alpha-amino acids, under the supervision of Prof. Giovanni Casiraghi.

v      In 1999 she received her Ph.D. degree in Bioorganic Chemistry from the University of Torino working on the exploitation of heterocyclic silyloxy dienes in the synthesis of densely functionalized chiral compounds.

v      In the fall of 1999 she joined the BioOrganicSynthesiS group (BOSS Group) directed by Prof. Giovanni Casiraghi at the Pharmaceutical Department of the University of Parma, where she obtained a position as researcher.

v      Since March 2000, she is Assistant Professor of Organic Chemistry at the Pharmaceutical Department of the University of Parma.

Main Research Subjects

v      Her main research interests are in the field of asymmetric synthesis of multifunctional natural and natural-like compounds, including carbasugars, conformationally constrained amino acids, densely functionalized heterocycles, nucleoside analogues.

v      More recently her major effort has been devoted to the development of a new class of integrin-targeted RGD-based pseudopeptide ligands for molecular recognition and biomedical applications.

 

Appointments

Appointments include the followings:

v      Member of Teaching Commettee of the Doctorate School “Design and Synthesis of Biologically Active Compounds” at the University of Parma (since 2007);

v      Member of the Scientific Commettee of Chemical Sciences 103 of the University of Parma (2005-2008).

 

Academic Activities

v      "Chimica Organica” (Organic Chemistry), 2nd year of the Specialist Degree Course in Pharmacy., Faculty of Pharmacy, University of Parma (since 2000)

 

Scientific Publications

v      She has co-authored more than 40 research papers and review articles, 2 patents and about 20 communications at national and international conferences.

 

Recent Funded Research Projects

v      PRIN2000 Member of Research Unit (PR) years 2001-2002

v      PRIN2002 Member of Research Unit(PR) years 2002-2003

v      PRIN2004 Member of Research Unit(PR) years 2004-2005

v      PRIN2006 Member of Research Unit(PR) years 2006-2007

 

Dr. Lucia Battistini ─ List of publications

 

Research papers and review articles

 

1.         Rassu, G.; Zanardi, F.; Battistini, L.; Casiraghi, G. Diastereoselective Synthesis of a-C-Arabinofuranosyl Glycine. Tetrahedron: Asymmetry 1995, 6, 371-374.

2.         Zanardi, F.; Battistini, L.; Rassu, G.; Cornia, M.; Casiraghi, G. g-Substituted Pyrrole-Based Silyl Dienol Ethers as a-Amino Acid Enolate Equivalents: A Versatile Entry to Racemic a-Substituted a-Amino Acids. J. Chem. Soc. Perkin Trans. 1 1995, 2471-2475.

3.         Spanu, P.; Rassu, G.; Ulgheri, F.; Zanardi, F.; Battistini, L.; Casiraghi, G. Total Syntheses of 3-Amino-3-deoxy- and 4-Amino-4-deoxyhexoses. Tetrahedron 1996, 52, 4829-4838.

4.         Zanardi, F.; Battistini, L.; Nespi, M.; Rassu, G.; Spanu, P.; Cornia, M.; Casiraghi, G. Total Synthesis of Both Enantiomers of trans-2,3-cis-3,4-Dihydroxyproline. Tetrahedron: Asymmetry 1996, 7, 1167-1180.

5.         Rassu, G.; Zanardi, F.; Battistini, L.; Gaetani, E.; Casiraghi, G. Expeditious Syntheses of Sugar-Modified Nucleosides and Collections Thereof Exploiting Furan-, Pyrrole-, and Thiophene-Based Siloxy Dienes. J. Med. Chem. 1997, 40, 168-180.

6.         Rassu, G.; Pinna, L.; Spanu, P.; Zanardi, F.; Battistini, L.; Casiraghi, G. Parallel, Stereoselective Syntheses of both Enantiomers of Muricatacin and their Sulfur and Nitrogen Relatives Using the Siloxydiene-Based Methodology. J. Org. Chem. 1997, 62, 4513-4517.

7.         Spanu, P.; Rassu, G.; Pinna, L.; Battistini, L.; Casiraghi, G. Diastereoselective Synthesis of D-erythro-sphingosine. Tetrahedron: Asymmetry 1997, 8, 3237-3243.

8.         Casiraghi, G.; Rassu, G.; Zanardi, F.; Battistini, L. Asymmetric Access to Functional, Structurally Diverse Molecules Exploiting Five-Membered Heterocyclic Silyloxy Dienes. In Advances in Asymmetric Synthesis; Hassner, A., Ed.; JAI Press: Stamford; 1998, Vol. 3, pp 113-189.

9.         Battistini, L.; Zanardi, F.; Rassu, G.; Spanu, P.; Pelosi, G.; Gasparri Fava, G.; Belicchi Ferrari, M.; Casiraghi, G. Total Synthesis of Both Enantiomers of trans-b-Hydroxypipecolic Acid. Tetrahedron: Asymmetry 1997, 8, 2975-2987.

10.      Zanardi, F.; Battistini, L.; Rassu, G.; Pinna, L.; Mor, M.; Culeddu, N.; Casiraghi, G. Modular Approach toward the Construction of the Core Motifs of Annonaceous Acetogenins and Variants Thereof. J. Org. Chem. 1998, 63, 1368-1369.

11.      Casiraghi, G.; Zanardi, F.; Battistini, L.; Rassu, G.; Appendino, G. Current Advances in the Chemical Synthesis of Annonaceous Acetogenins and Relatives. ChemTracts-Org. Chem. 1998, 11, 803-827.

12.      Rassu, G.; Carta, P.; Pinna, L.; Battistini, L.; Zanardi, F.; Acquotti, D.; Casiraghi, G. Lewis Acid-Assisted Vinylogous Mannich and Mukaiyama-Aldol Reactions: A Route to Densely Hydroxylated Indolizidine Alkaloid Analogues. Eur. J. Org. Chem. 1999, 1395-1400.

13.      Battistini, L.; Rassu, G.; Pinna, L.; Zanardi, F.; Casiraghi, G. Diastereoselective Synthesis of a Novel Lactam Peptidomimetic Exploiting Vinylogous Mannich Addition of 2-Silyloxyfuran Reagents. Tetrahedron: Asymmetry 1999, 10, 765-773.

14.      Casiraghi, G.; Zanardi, F.; Battistini, L.; Appendino, G. Conceptually New Directed Aldol Condensation Using Aluminum Tris-(2,6-diphenylphenoxide). ChemTracts-Org. Chem. 1999, 12, 547-554.

15.      Rassu, G.; Zanardi, F.; Battistini, L.; Casiraghi, G. The Vinylogous Aldol Addition of Heterocyclic Silyloxy Dienes: Application in Synthesis. Synlett 1999, 1333-1350.

16.      Rassu, G.; Auzzas, L.; Pinna, L.; Zanardi, F.; Battistini, L.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives as Illustrated by Diastereoselective Synthesis of 1-Deoxy-1-amino-pseudo-b-D-gulopyranose (Alias 1,2,4-tri-epi-Validamine). Org. Lett. 1999, 1, 1213-1215.

17.      Rassu, G.; Zanardi, F.; Battistini, L.; Casiraghi, G. The Synthetic Utility of Furan-, Pyrrole- and Thiophene-Based 2-Silyloxy Dienes. Chem. Soc. Rev. 2000, 109-118.

18.      Zanardi, F.; Battistini, L.; Rassu, G.; Auzzas, L.; Pinna, L.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. The Utility of Furan, Pyrrole, and Thiophene 2-Silyloxy Dienes As Demonstrated by Modular Synthesis of Annonaceous Acetogenin Core Units and Their Pyrrolidine and Thiolane Analogues. J. Org. Chem. 2000, 65, 2048-2064.

19.      Rassu, G.; Auzzas, L.; Pinna, L.; Battistini, L.; Zanardi, F.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 1. Stereocontrolled Synthesis of Pseudo-b-D-gulopyranose, Pseudo-b-D-xylofuranose, (Pseudo-b-D-gulopyranosyl)amine, and (Pseudo-b-D-xylofuranosyl)amine. J. Org. Chem. 2000, 65, 6307-6318.

20.      Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Battistini, L.; Zanardi, F.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 2. Diversity-Based Synthesis of b-D-Xylo, b-D-Ribo, b-L-Arabino, and b-L-Lyxo 4a-Carbafuranoses, and (4a-Carbafuranosyl)thiols. J. Org. Chem. 2001, 66, 8070-8075 (web edition November 3rd, 2001).

21.      Zanardi, F.; Battistini, L.; Marzocchi, L.; Acquotti, D.; Rassu, G.; Pinna, L.; Auzzas, L.; Zambrano, V.; Casiraghi, G. Synthesis of a Small Repertoire of Non-Racemic 5a-Carbahexopyranoses and 1-Thio-5a-carbahexopyranoses. Eur. J. Org. Chem. 2002, 1956-1964.

22.      Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Zanardi, F.; Battistini, L.; Marzocchi, L.; Acquotti, D.; Casiraghi, G. Variable Strategy toward Carbasugars and Relatives. 4. Viable Access to (4a-Carbapentofuranosyl)amines, (5a-Carbahexopyranosyl)amines, and Amino Acids Thereof. J. Org. Chem. 2002, 67, 5338-5342 (web edition June 27th, 2002).

23.      Rassu, G.; Auzzas, L.; Zambrano, V.; Burreddu, P.; Battistini, L.; Curti, C. A Short Entry to Novel C(2)-Methyl Branched 4a-Carbafuranoses. Tetrahedron: Asymmetry 2003, 14, 1665-1670.

24.      Rassu, G.; Auzzas, L.; Pinna, L.; Zambrano, V.; Zanardi, F.; Battistini, L.; Gaetani, E.; Curti, C.; Casiraghi, G. Variable Strategy towards Carbasugars and Relatives. 5. Focus on Preparation of Chiral Nonracemic Medium-Sized Carbocycles. J. Org. Chem., 2003, 68, 5881-5885 (web release date June 27th, 2003).

25.      Rassu, G.; Auzzas, L.; Pinna, L.; Battistini, L.; Curti, C. Advances in Chemical Synthesis of Carbasugars and Analogues. In Studies in Natural Products Chemistry; Atta-ur-Rahman, Ed.; Elsevier Science B. V.: Amsterdam; 2003, Vol. 29: Bioactive Natural Products (Part J), pp 449-520 (ISBN : 0-444-51510-0).

26.      Battistini, L.; Casiraghi, G.; Curti, C.; Rassu, G.; Zambrano, V.; Zanardi, F. Silylative N-hydroxyalkylation of amide compounds: application to the synthesis of acyclic alditol-based nucleoside analogues. Tetrahedron 2004, 60, 2957-2964.

27.      Rassu, G.; Auzzas, L.; Zambrano, V.; Burreddu, P.; Pinna, L.; Battistini, L.; Zanardi, F.; Casiraghi, G. Variable Strategy towards Carbasugars and Relatives. 6. Diastereoselective Synthesis of 2-Deoxy-2-amino-5a-carba-b-L-mannopyranuronic Acid and 2-Deoxy-2-amino-5a-carba-b-L-mannopyranose. J. Org. Chem., 2004, 69, 1625-1628 (web release date February 2nd, 2004).

28.      Rassu, G.; Auzzas, L.; Battistini, L.; Casiraghi, G. Advances in The Chemical Synthesis of Medium-Sized Cyclitols. Mini-Reviews in Organic Chemistry 2004, 1, 343-357.

29.      Battistini, L.; Curti, C.;  Zanardi, F.; Rassu, G.; Auzzas, L.; Casiraghi, G. Enantioselective Total Synthesis of (1R,3S,4R,5R)-1-Amino-4,5-dihydroxycyclopentane-1,3-dicarboxylic Acid. A Full-Aldol Access to Carbaketose Derivatives. J. Org. Chem. 2004, 69, 2611-2613 (web release date March 4th, 2004).

30.      Casiraghi, G.; Rassu, G.; Auzzas, L.; Burreddu, P.; Gaetani, E.; Battistini, L.; Zanardi, F.; Curti, C.; Nicastro, G.; Belvisi, L.; Motto, I.; Castorina, M.; Giannini, G.; Pisano, C. Grafting Aminocyclopentane Carboxylic Acids onto the RGD Tripeptide Sequence Generates Low Nanomolar aVb3/aVb5 Integrin Dual Binders. J. Med. Chem. 2005, 48, 7675-7687.

31.      Curti, C.; Zanardi, F.; Battistini, L.; Sartori, A.; Rassu, G.; Auzzas, L.; Roggio, A.; Pinna, L.; Casiraghi, G. New Enantioselective Entry to Cycloheptane Amino Acid Polyols. J. Org. Chem. 2006, 71, 225-230.

32.      Curti, C.; Zanardi, F.; Battistini, L.; Sartori, A.; Rassu, G.; Pinna, L.; Casiraghi, G. Streamlined, Asymmetric Synthesis of 8,4'-Oxyneolignans. J. Org. Chem. 2006, 71, 8552-8558.

33.      Zanardi, F.; Sartori, A.; Curti, C.; Battistini, L.; Rassu, G.; Nicastro, G.; Casiraghi, G. Diastereoselective Synthesis of 4,5'-Bis-Proline Compounds via Reductive Dimerization of N-Acyloxyiminium Ions. J. Org. Chem. 2007, 72, 1814-1817.

34.      Zanardi, F.; Burreddu, P.; Rassu, G.; Auzzas, L.; Battistini, L.; Curti, C.; Sartori, A.; Nicastro, G.; Menchi, G.; Cini, N.; Bottoncetti, A.; Raspanti, S.; Casiraghi, G. Discovery of Subnanomolar Arginine-Glycine-Aspartate-Based aVb3/aVb5 Integrin Binders Embedding 4-Aminoproline Residues. J. Med. Chem. 2008, 51 (6), 1771-1782 (corigendum J. Med. Chem. 2008, 51, 2870).

35.      Zanardi, F.; Curti, C.; Sartori, A.; Rassu, G.; Roggio, A.; Battistini, L.; Burreddu, P.; Pinna, L.; Pelosi, G.; Casiraghi, G. Further Uses of Pyrrole-Based Dienoxysilane Synthons: A Full Aldol Approach to Azabicyclo[x.2.1]alkane Systems. Eur. J. Org. Chem. 2008, 2273-2287.

36.      Curti, C.; Sartori, A.; Battistini, L.; Rassu, G.; Burreddu, P.; Zanardi, F.; Casiraghi, G. Vicarious Silylative Mukaiyama Aldol Reaction: A Vinylogous Extension. J. Org. Chem. 2008, 73, 5446-5451 (DOI: 10.1021/jo800741c).

37.      Sartori, A.; Curti, C.; Battistini, L.; Burreddu, P.; Rassu, G.; Pelosi, G.; Casiraghi, G.; Zanardi, F. Direct-type vinylogous Mukaiyama-Michael additino reactions involving pyrrolinone donors. Tetrahedron 2008, 64, 11697-11705.

38.      Casiraghi, G.; Zanardi, F.; Battistini, L.; Rassu, G. Advances in Exploring Heterocyclic Dienoxy Silane Nucleophiles in Asymmetric Synthesis Synlett 2009, 1525-1542.

39.      Curti, C.; Sartori, A.; Battistini, L.; Rassu, G.; Zanardi, F.; Casiraghi, G. Asymmetric, catalytic, vinylogous aldol reactions using pyrrole-based dienoxy silanes. Enantioselective synthesis of a,b-unsaturated g-butyrolactam synthons. Tetrahedron Lett. 2009, 50, 3428-3431.

40.      Battistini, L.; Burreddu, P.; Carta, P.; Rassu, G.; Auzzas, L.; Curti, C.; Zanardi, F.; Manzoni, L.; Araldi, E. M. V.; Scolastico, C.; Casiraghi, G. 4-Aminoproline-Based Arginine-Glycine-Aspartate Integrin Binders with Exposed Ligation Points: Practical in-Solution Synthesis, Conjugation and Binding Affinity Evaluation. Org. Biomol. Chem., 2009, 7, 4924-4935 (doi: 10.1039/b914836a).

 

 

Patents

1.                  Casiraghi, G.; Rassu, G.; Auzzas, L.; Battistini, L.; Zanardi, F.; Curti, C.; Nicastro, G.; Belvisi, L.; Castorina, M.; Giannini, G.; Pisano, C. Ciclopeptidi Ibridi Contenenti Amminoacidi Cicloalcanici, e Loro Preparazione ed Uso. Ital. Pat. Appl. RE2005A00088, 21.07.05.

2.                  Casiraghi, G.; Scolastico, C.; Zanardi, F.; Battistini, L.; Curti, C.; Rassu, G.; Auzzas, L.; Burreddu, P.; Manzoni, L. P. Integrin Targeted Cyclopeptide Ligands, Their Preparation and Use. EP N° 07003540.7, 21.02.2007;

PCT Appl., N° PCT/IB2008/000366, 19.02.2008; USA Application Serial N° 12/527,603.