Università degli Studi di Parma
Dipartimento Farmaceutico

Scientific Production 2008

I.Scientific papers
II.Reviews and book chapters
III.Proceedings
IV.Conference communications
V.Invited speakers
VI.Chairpersons
VII.Awards
VIII.Visiting researchers
IX.Visiting students
X.Visiting students Program Socrates/Erasmus
XI.Visting teachers Program Socrates/Erasmus
XII. Patents

I. Scientific papers

  1) C. Padula, A. Pappani, P. Santi. “In vitro permeation of levothyroxine across the skin”, International Journal of Pharmaceutics, 349, 161-165 (2008).

  2) S. Rivara, A. Lodola, M. Mor, A. Bedini, G. Spadoni, V. Lucini, M. Pannacci, F. Fraschini, F. Scaglione, R.O. Sanchez, G. Gobbi, G. Tarzia. “N-(substituted-anilinoethyl)amides: design, synthesis, and pharmacological characterization of a new class of melatonin receptor Ligands”, Journal of Medicinal Chemistry, 50, 6618-6626 (2007).

  3)  A. Lodola, M. Mor, S. Rivara, C. Christov, G. Tarzia, D. Piomelli, A.J. Mulholland. “Identification of productive inhibitor binding orientation in fatty acid amide hydrolase (FAAH) by QM/MM mechanistic modelling”, Chemical Communication, 214-216 (2008).

  4)  A.R. King, A. Duranti, A. Tontini, S. Rivara, A. Rosengarth, J.R. Clapper, G. Astarita, J.A. Geaga, H. Luecke, M. Mor, G. Tarzia, D. Piomelli. “URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonoylglycerol degradation in intact brain slices”, Chemistry & Biology, 14, 1357-1365 (2007).

  5) R.P. Raffin, P. Colombo, F. Sonvico, F.S. Polleto, G. Colombo, A. Rossi, A.R. Pohlmann, S.S. Guterres. “Soft agglomerates of pantoprazole gastro-resistant microparticles for oral administration and intestinal release”, Journal of Drug Delivery Science and Technology, 17 (6), 407-413 (2007).

  6) F. Vacondio, C. Silva, A. Fioni, M. Mor, M. Rivara, F. Bordi, L. Flammini, V. Ballabeni, E. Barocelli. “Development and validation of a LC-MS method with electrospray ionization for the determination of the imidazolo H₃ antagonist ROS203 in rat plasma”, Journal of Pharmaceutical and Biomedical Analysis, 46, 200-205 (2008).

  7) M. Rivara, F. Vacondio, C. Silva, V. Zuliani, M. Fantini, F. Bordi, P.V. Plazzi, S. Bertoni, V. Ballabeni, L. Flammini, E. Barocelli, M. Mor. “Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H₃ receptor”, Chemistry & Biodiversity, 5, 140-152 (2008).

  8)  F. Buttini, P. Colombo, M.P.E. Wenger, P. Mesquida, C. Marriott, S.A. Jones. “Back to basics: the development of a simple, homogenous, two component dry-powder inhaler formulation for the delivery of budesonide using miscible vinyl polymers”, Journal of Pharmaceutical Sciences, 97 (3), 1257-1267 (2008).

  9)  F. Buttini, A. Soltani, P. Colombo, C. Marriott, S.A. Jones. “Multilayer PVA adsorption onto hydrophobic drug substrates to engineer drug-rich microparticles”, European Journal of Pharmaceutical Sciences, 33, 20-28 (2008).

10)  I. Pasquali, R. Bettini, F. Giordano. “Supercritical fluid technologies: an innovative approach for manipulating the solid-state of pharmaceuticals”, Advanced Drug Delivery Reviews, 60, 399-410 (2008).

11)  A. Cavazzoni, R.R. Alfieri, C. Carmi, V. Zuliani, M. Galetti, C. Fumarola, R. Frazzi, M. Bonelli, F. Bordi, A. Lodola, M. Mor, P.G. Petronini. “Dual mechanism of action of the 5-benzylidene-hydantoin UPR1024 on lung cancer cell lines”, Molecular Cancer Therapeutics, 7 (2), 361-370 (2008).

12)  G. Cocconcelli, E. Diodato, A. Caricasole, G. Gaviraghi, E. Genesio, C. Ghiron, L. Magnoni, E. Pecchioli, P.V. Plazzi, G.C. Terstappen. “Aryl azoles with neuroprotective activity – Parallel synthesis and attempts at target identification”, Bioorganic & Medicinal Chemistry, 16, 2043-2052 (2008).

13)  Y. Gerelli, M.T. Di Bari, A. Deriu, L. Cantù, P. Colombo, C. Como, S. Motta, F. Sonvico, R. May. “Structure and organization of phospholipid/polysaccharide nanoparticles”, Journal of Physics: Condensed Matter, 20 (10), #104211 (8pp) (2008).

14)  S. Nicoli, S. Cella, V. Aversa, P. Santi. “Transdermal film containing nicotine and bupropion for combined smoking cessation therapy”, Pharmaceutical Technology Europe, 22-29 (February 2008).

15)  G. Colombo, C. Terzano, P. Colombo, A. Petroianni, A. Ricci, F. Buttini. “Methacholine dry powder inhaler as a new tool for bronchial challenge test”, International Journal of Pharmaceutics, 352, 165-171 (2008).

16)  F. Zanardi, P. Burreddu, G. Rassu, L. Auzzas, L. Battistini, C. Curti, A. Sartori, G. Nicastro, G. Menchi, N. Cini, A. Bottoncetti, S. Raspanti, G. Casiraghi. “Discovery of subnanomolar arginine-glycine-aspartate-based αvβ3/αvβ5 integrin binders embedding 4-aminoproline residues”, Journal of Medicinal Chemistry, 51, 1771-1782 (2008).

17)  P. Vicini, A. Geronikaki, M. Incerti, F. Zani, J. Dearden, M. Hewitt. “2-Heteroarylimino-5-benzylidene-4-thiazolidinones analogues of 2-thiazolylimino-5-benzylidene-4-thiazolidinones with antimicrobial activity: synthesis and structure-activity relationship”, Bioorganic & Medicinal Chemistry, 16, 3714-3724 (2008).

18)  M.T. Di Bari, Y. Gerelli, F. Sonvico, A. Deriu, F. Cavatorta, G. Albanese, P. Colombo, F. Fernandez-Alonso. “Dynamics of lipid-saccharide nanoparticles by quasielastic neutron scattering”, Chemical Physics, 345, 239-244 (2008).

19)  C. Christov, T. Karabencheva, A. Lodola. “Aromatic interactions and rotational strenghts within protein environment: an electronic structural study on β-lactamases from class A”, Chemical Physics Letters, 456, 89-95 (2008).

20)  F. Zanardi, C. Curti, A. Sartori, G. Rassu, A. Roggio, L. Battistini, P. Burreddu, L. Pinna, G. Pelosi, G. Casiraghi. “Further uses of pyrrole-based dienoxysilane synthons: a full aldol approach to azabicyclo[x.2.1]alkane systems”, European Journal of Organic Chemistry, 2273-2287 (2008).

21)  F. Tamimi, J. Torres, R. Bettini, F. Ruggera, C. Rueda, M. López-Ponce, E. Lopez-Cabarcos. “Doxycycline sustained release from brushite cements for the treatment of periodontal diseases”, Journal of Biomedical Material Research Part A, 707-714 (2008).

22)  I. Pasquali, L. Comi, F. Pucciarelli, R. Bettini. “Swelling, melting point reduction and solubility of PEG 1500 in supercritical CO₂”, International Journal of Pharmaceutics, 356, 76-81 (2008).

23)  S. Nicoli, F. Zani, S. Bilzi, R. Bettini, P. Santi. “Association of nicotinammide with parabens: effect on solubility, partition and transdermal permeation”, European Journal of Pharmaceutics and Biopharmaceutics, 69, 613-621 (2008).

24)  C.Z. Christov, T.G. Karabencheva, A. Lodola. “Relationship between chiroptical properties, structural changes and interactions in enzymes: a computational study on β-lactamases from class A”, Computational Biology and Chemistry, 32, 167-175 (2008).

25)  F. Marra, J.-L. Levy, P. Santi, Y.N. Kalia. “In vitro evaluation of the effect of electrotreatment on skin permeabilità”, Journal of Cosmetic Dermatology, 7, 105-111 (2008).

26)  I. Pasquali, J.-M. Andanson, S.G. Kazarian, R. Bettini. “Measurement of CO₂ sorption and PEG 1500 swelling by ATR-IR spectroscopy”, Journal of Supercritical Fluids, 45, 384-390 (2008).

27)  S. Nicoli, C. Padula, V. Aversa, B. Vietti, P.W. Wertz, A. Millet, F. Falson, P. Govoni, P. Santi. “Characterization of rabbit ear skin as a skin model for in vitro transdermal permeation experiments: histology, lipid composition and permeability, Skin Pharmacology and Physiology, 21, 218-226 (2008).

28)  O.L. Strusi, F. Sonvico, R. Bettini, P. Santi, G. Colombo, P. Barata, A. Oliveira, D. Santos, P. Colombo. “Modul assemblage technology for floating systems: in vitro and in vivo gastro-retention”, Journal of Controlled Release, 129, 88-92 (2008).

29)  M. Mor, A. Lodola, S. Rivara, F. Vacondio, A. Duranti, A. Tontini, S. Sanchini, G. Piersanti, J.R. Clapper, A.R. King, G. Tarzia, D. Piomelli. “Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of bipheyl-3-yl alkylcarbamates”, Journal of Medicinal Chemistry, 51, 3487-3498 (2008).

30)  P. Scarfato, E. Avallone, P. Iannelli, R.P. Aquino, M.R. Lauro, A. Rossi, D. Acierno. “Quercetin microspheres by solvent evaporation: preparation, characterization and release behavior”, Journal of Applied Polymer Science, 109, 2994-3001 (2008).

31)  C. Curti, A. Sartori, L. Battistini, G. Rassu, P. Burreddu, F. Zanardi, G. Casiraghi. “Vicarious silylative Mukaiyama aldol reaction: a vinylogous extension”, Journal of Organic Chemistry, 73, 5446-5451 (2008).

32)  S. Vezzosi, A.G. Ferré, M. Crucianelli, C. Crestini, R. Saladino. “A novel and efficient catalytic epoxidation of olefins with adducts derived from methyltrioxorhenium and chiral aliphatic amines”, Journal of Catalysis, 257, 262-269 (2008).

33)  R. Tozzi, N. Mulinacci, K. Stolikken, I. Pasquali, F.F. Vincieri, R. Bettini. “Supercritical extraction of carotenoids from Rosa canina L. Hips and their formulation with b-cyclodextrin”, AAPS PharmSciTech, 9 (2), 693-700 (2008).

34)  S. Rivara, M. Mor, A. Bedini, G. Spadoni, G. Tarzia. “Melatonin receptor agonist: SAR and applications to the treatment of sleep-wake disorders”, Current Topics in Medicinal Chemistry, 8, 954-968 (2008).

35)  A. Geronikaki, P. Eleftheriou, P. Vicini, I. Alam, A. Dixit, A.K. Saxena. 2-Thiazolylimino/heteroarylimino-5-arylidene-4-thiazolidinones as new agents with SHP-2 inhibitory action, Journal of Medicinal Chemistry, 51, 5221-5228 (2008).

36)  S. Nicoli, S. Bilzi, P. Santi, M.R. Caira, J. Li, R. Bettini. “Ethyl-paraben and nicotinamide mixtures: apparent solubility, thermal behavior and X-ray structure of the 1:1 co-crystal”, Journal of Pharmaceutical Sciences, 97 (11), 4830-4839 (2008).

37)  C. Padula, N. Campana, P. Santi. “Simultaneous determination of benzophenone-3, retinol and retinyl acetate in pig ear skin layers by high-performance liquid hromatography”, Biomedical Chromatography, 22, 1060-1065 (2008).

38)  A. Nussinovitch, A. Gal, C. Padula, P. Santi. “Physical characterization of a new skin bioadhesive film”, AAPS PharmSciTech, 9 (2), 458-463 (2008).

39)  M. Rivara, A.R. Baheti, M. Fantini, G. Cocconcelli, C. Ghiron, C.L. Kalmar, N. Singh, E.C. Merrick, M.K. Patel, V. Zuliani. “2,4(5)-Diarylimidazoles: Synthesis and biological evaluation of a new class of sodium canne blockers against hNa_v1.2”, Bioorganic & Medicinal Chemistry Letters, 18, 5460-5462 (2008).

40)  A. Lodola, C.J. Woods, A.J. Mulholland. “Applications and advances of QM/MM methods in computational enzymology”, Annual Reports in Computational Chemistry, 4, 155-169 (2008).

41)  Y. Gerelli, S. Barbieri, M.T. Di Bari, A. Deriu, L. Cantù, P. Brocca, F. Sonvico, P. Colombo, R. May, S. Motta. “Structure of self-organized multiplayer nanoparticles for drug delivery”, Langmuir, 24, 11378-11384 (2008).

42)  S. Bertoni, V. Ballabeni, L. Flammini, F. Saccani, G. Domenichini, G. Morini, M. Comini, M. Rivara, E. Barocelli. “In vitro and in vivo pharmacological analysis of imidazolo-free histamine H₃ receptor antagonists: promising results for a brain-penetrating H₃ blocker with weak anticholinesterase activity”, Naunyn-Schmiedeberg’s Archives of Pharmacology, 378, 335-343 (2008).

43)  M. Incerti, D. Acquotti, P. Vicini. “Complete ¹H and ¹³C NMR spectral assignment of benzo[d]isothiazole derivatives and of an isoindole isoster”, Magnetic Resonance in Chemistry, 46, 1175-1179 (2008).

44)   I. Pasquali, R. Bettini. “Are pharmaceutics really going supercritical ?”, International Journal of Pharmaceutics, 364, 176-187 (2008).

45)  A. Sartori, C. Curti, L. Battistini, P. Burreddu, G. Rassu, G. Pelosi, G. Casiraghi, F. Zanardi. “Direct-type vinylogous Mukaiyama-Michael addition reactions involving pyrrolinone donors”, Tetrahedron, 64, 11697-11705 (2008).

46)  G. Morini, M. Comini, M. Rivara, S. Rivara, F. Bordi, P.V. Plazzi, L. Flammini, F. Saccani, S. Bertoni, V. Ballabeni, E. Barocelli, M. Mor. “Synthesis and structure- activity relationships for biphenyl H₃ receptor antagonists with moderate anti-cholinesterase activity”, Bioorganic & Medicinal Chemistry, 16, 9911-9924 (2008).

47)  C. Mucignat, A. Cavaggioni, M. Redaelli, M. Malatesta, C. Zancanaro, A. Caretta. “Selective distribution of protein kinase A regulatory subunit RIIalpha in rodent gliomas”, Neuro-Oncology, 10, 958-967 (2008).

48)  M. Redaelli, A. Cavaggioni, C. Mucignat, S. Cavirani, A. Caretta, G. Donofrio. “Transduction of the rat brain by Bovine Herpesvirus 4”, Genetic Vaccines and Therapy, 6, 6 (2008).

49) L. Ferrarese, F. Zani, A. Uccello, A. Ghirardini. “Lichene islandico: attività antimicrobica e applicazioni fitocosmetiche”, Cosmetic Technology, 11(2), 25-28 (2008).

II. Book Chapters   

  1) P. Colombo, P. Santi, J. Siepmann, G. Colombo, F. Sonvico, A. Rossi, O.L. Strusi. “Swellable and rigid matrices: controller release matrices with cellulose ethers”, in “Pharmaceutical Dosage Forms: Tablets”, vol. 2: Rational Design and Formulatione, edited by Larry L. Augsburger, Steohen W. Hoag, Informa Healthcare, 433-468 (2008).

  2) G. Spadoni, A. Bedini, M. Mor, S. Rivara. “The rationale for the development of melatonin receptor ligands”, in “Sleep Disorders: Diagnosis and Therapeutics”, Informa Healthcare, 402-416 (2008).

III. Proceedings

  1) S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, P. Santi. “In vitro transscleral iontophoresis of high molecular weight neutral compounds”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April 7^th-10^th (2008).

  2) D.R. de Araujo, F. Marra, C. Padula, P. Santi. “Transdermal delivery of fentanyl from Patch-non-Patch^® films: in vitro permeation studies”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April 7^th-10^th (2008).

  3) R. Oliveira, P. Barata, F. Veiga, D. Ferreira, D. Santos, C. Padula, S. Nicoli, P. Santi. “Effect of cyclodextrin complexation on the permeation of naproxen from a bioadhesive film”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April 7^th-10^th (2008).

  4) C. Balaguer-Fernandez, C. Padula, A. Femenia-Font, V. Marino, A. Lopez-Castellano, F. Marra, S. Nicoli, P. Santi, “In vivo bioadhesive evaluation of sumatriptan succinate transdermal films”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April 7^th-10^th (2008).

  5) D.R. de Araujo, C. Padula, P. Santi. “Permeation of benzocaine across pig ear skin from bioadhesive films”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April 7^th-10^th (2008).

  6) F. Buttini, C. Grainger, S.A. Jones, P.G. Royall, G.P. Martin, B. Forbes. “Characterization of particles emitted from two formulations of beclomethasone dipropionate solution metered dose inhalers”, Respiratory Drug Delivery 2008, Scottsdale, Arizona (U.S.A.), May 11^th-15^th, 2008.

  7) G. Colombo, C. Terzano, P. Colombo, A. Petroianni, A. Ricci, F. Buttini. “A clinical study of a methacholine dry powder for the bronchial challenge test, Respiratory Drug Delivery 2008, Scottsdale, Arizona (U.S.A.), May 11^th-15^th, 2008.

  8) C. Parlati, H. Adi, F. Buttini, P. Colombo, P.M. Young, D. Traini. “In vitro evaluation oc co-processed antibiotic for inhalation”, Respiratory Drug Delivery 2008, Scottsdale, Arizona (U.S.A.), May 11^th-15^th, 2008.

  9) S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, P. Santi. “Characterization of human and porcine sclera as in vitro models for transscleral drug delivery”, International Symposium Controlled Release Bioactive Materials, New York (U.S.A.), July, 12^th-16^th, 2008.

10) A. Fioni, F. Vacondio, M. Mor, C. Silva, A. Lodola, A. Duranti, A. Tontini, G. Tarzia, D. Piomelli. “Quantitative structure-property relationships of a class of carbamatebased fatty acid amide hydrolase (FAAH) inhibitors”, in: EUROQSAR-08, The 17^th European Symposium on Quantitative Stucture-Activity Relationships and Omics Technologies and Systems Biology, EuroQSAR-08, Uppsala (Sweden), September, 21^st-26^th, 2008 (pp. 170-171).

IV.Conference communications

  1) S. Nicoli, G. Ferrari, M. Quarta, P. Govoni, P. Santi. “Effect of iontophoresis on the in-vitro transscleral transport of high molecular weight neutral compounds”, ISOPT, Budapest (Hungary), February, 28^th-March, 2^nd, 2008. (P)

  2) A. Geronikaki, J.C. Dearden, M. Incerti, P. Vicini. “QSAR analysis of 4-thiazolidinone derivatives with antimicrobial activity”, EAMHC-5 5th Eurasian Meeting on Heterocyclic Chemistry, Al Kuwayt (Kuwait), March, 1^st-6^th, 2008. (P)

  3) A.G. Balducci, C. Conti, A. Rossi, F. Sonvico, P. Colombo. “A study for the development of coated mesalazine granules for the colonic delivery in pediatric patients”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (C)

  4) M.B. Pranzo, M. Coruzzi, R. Bettini. “Solubility and solid state characterization of albendazole polymorphs”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (C)

  5) S. Mercuri, O.L. Strusi, F. Sonvico, R. Bettini, P. Colombo. “Investigation of floating properties of assembled system drug delivery built using Dome Matrix technology”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (C)

  6) A. Vitale, F. Sonvico, C. Parlati, P. Colombo, F. Buttini. “The respirability investigation of insulin dry powders obtained by spray drying technique”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (P)

  7) C. Como, S. Barbieri, F. Sonvico, A. Rossi, P. Colombo. “An innovative system for tamoxifen oral delivery: from nanoparticles to micronized powder”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (P)

  8)  P. Crepaldi, F. Sonvico, P. Del Gaudio, A. Cariani, F. Bortolotti, E. Menegatti, G. Colombo. “Bioencapsulation methods for cell inclusion in polysaccharidic matrices for clinical applications”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (P)

  9) R. Menabeni, R. Tozzi, I. Pasquali, R. Bettini. “Pharmaceutical characterization of the relative stability of two didanosine polymorphs”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (P)

10) F. Gliyennet, C. Padula, F. Marra, P. Santi. “Dermal patch for the treatment of acne”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (P)

11)  C. Parlati, H. Adi, P. Colombo, P.M. Young, D. Traini. “Characterisation of lipid-coated tobramycin dry powder inhaler formulation”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (P)

12)  F. Sansone, M. Pesca, G. Dello Russo, P. Russo, P. Del Gaudio, P. Colombo, R.P. Aquino. “Innovative dry powder formulations of flavonoide against oxidative stress in airways disease”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (P)

13)  R. Tozzi, A. Romani, A. Borghetti, R. Bettini. “Chitosan-based tabular scaffold for bile duct reconstruction”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008. (P)

14)  R. Oliveira, P. Barata, F. Veiga, D. Ferreira, D. Santos, C. Padula, S. Nicoli, P. Santi. “Effect of cyclodextrin complexation on the permeation of naproxen from a bioadhesive film”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

15)  C. Balaguer-Fernández, C. Padula, A. Femenía-Font, V. Merino, A. López-Castellano, F. Marra, S. Nicoli, P. Santi. “In vivo biohadesive evaluation of sumatriptan succinate transdermal films”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

16)  S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, P. Santi. “In-vitro transscleral iontophoresis of high molecular weight neutral compounds”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

17)  D.R. De Araujo, F. Marra, C. Padula, P. Santi. “Transdermal delivery of fentanyl from Patch-non-patch^® films: in vitro permeation studies”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

18)  R. Tozzi, M.R. Caira, L. Marcelloni, C. Pezzarossa, R. Bettini. “Midazolam hydrochloride hydrate: solubility in water-propylene glicol mixtures and solid state characterization”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

19)  P. Del Gaudio, P. Russo, A. Feola, M.G. Garofalo, P. Colombo, R.P. Aquino. “Ketoprofen and ketoprofen-lysinate loaded alginate beads by laminar jet break-up technology”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

20)  A. Rossi, B.J. De Haan, F. Sonvico, P. De Vos, P. Colombo. “Study of human protein adsorption onto sodium alginate/poly-L-lysine beads by micro fourier transformed infrared spectroscopy”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

21)  F. Sonvico, G. Sacchetti, F. Gussago, S. Barbieri, A. Rossi, P. Colombo, P. Carbognani. “Polysaccharidic films loaded with cisplatin for the locoregional therapy of pleural malignant mesotelioma”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

22)  F. Buttini, S. Cagnani, A. Vitale, P. Colombo. “Pharmaceutical development of insulin dry powders for inhalation prepared by spray drying method”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

23)  R. Cortesi, M. Drechsler, A. Rossi, E. Menegatti, R. Manservigi, E. Esposito. “Niosomes for vaginal administration of an antiherpetic peptide”, 6^th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona (Spain), April, 7^th-10^th, 2008. (P)

24)  A. Rossi, B.J. De Haan, F. Sonvico, P. De Vos, P. Colombo. “Study of surface adsorption on sodium alginate/poly-L-lysine beads by M-FTIR”, COST865 Spring 2008 Meeting: Bioencapsulation Sciences to Applications, Ljubljana (Slovenia), April 25^th-26^th, 2008. (P)

25)  S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, P. Santi. “In vitro passive and iontophoretic permeation of insulin through human sclera, ARVO annual meeting, Fort Lauderdale, (Florida, U.S.A.), April 27^th-May 1^st, 2008. (P)

26)  G. Valitutti, A. Duranti, A. Lodola, M. Mor, G. Piersanti, D. Piomelli, S. Rivara, A. Tontini, G. Tarzia, P. Traldi. “The collisional behavior of esi-generated protonated molecules of some carbamate bioisosters and its relationship with their biological activity”, 26^th Informal Meeting on Mass Spectrometry, Fiera di Primiero (TN, Italy), May 2008, 4^th-8^th, 2008. (P)

27)  O.L. Strusi, S. Mercuri, F. Sonvico, G. Colombo, P. Colombo. “Physical and in vitro floatation characteristics of drug delivery system made of Dome Matrix^® module assembly”, 2008 Asean Scientific Conference in Pharmaceutical Technology, Penang (Malaysia), June, 1^st-3^rd, 2008. (O)

28)  A.G. Balducci, G. Corace, C. Cavallari, L. Rodriguez, P. Colombo, F. Sonvico, A. Rossi, G. Colombo. “A study for the development of mesalazine multiparticulate dosage forms for colon delivery in pediatric patients”, 2008 Asean Scientific Conference in Pharmaceutical Technology, Penang (Malaysia), June, 1^st-3^rd, 2008. (P)

29)  C. Parlati, H. Adi, P.M. Young, D. Traini, P. Colombo. “High respirable tobramycin powders for inhalation”, 2008 Asean Scientific Conference in Pharmaceutical Technology, Penang, Malaysia, June, 1^st-3^rd, 2008. (P)

30)  R. Tozzi, A.A. Romani, P. Soliani, A. Borghetti, R. Bettini. “Chitosan scaffold for bile duct reconstructive surgery”, Termis-EU 2008 Annual Meeting, Porto (Portugal), June, 22^nd-26^th, 2008. (P)

31) D.R. De Araujo, C. Padula, P. Santi. “Permeation of benzocaine across pig ear skin from bioadhesive films”, 35^th Annual Meeting and Exposition of the Controlled Release Society, New York (New York, U.S.A.), July, 12^th-16^th, 2008. (P)

32) S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, P. Santi. “Characterization of human and porcine sclera as in vitro models for transscleral drug delivery”, 35^th Annual Meeting and Exposition of the Controlled Release Society, New York (New York, U.S.A.), July, 12^th-16^th, 2008. (C)

33) R. Tozzi, A.A. Romani, P. Soliani, A. Borghetti, R. Bettini. “Chitosan tube-shaped scaffold for bile duct reconstruction”, 35^th Annual Meeting and Exposition of the Controlled Release Society, New York (New York, U.S.A.), July, 12^th-16^th, 2008. (P)

34) I. Pasquali, L. Pezzini, R. Menabeni, R. Bettini. “PEG microparticles loaded with diazepam obtained by particles from gas saturation solution technique: production, characterization and in vitro dissolution”, 35^th Annual Meeting and Exposition of the Controlled Release Society, New York (New York, U.S.A.), July, 12^th-16^th, 2008. (P)

35) Caretta, C. Mucignat. “Distribution of protein kinase A regulatory subunits in the chicken brain”, FENS, Federation of European Neuroscience Societies, Geneve (Switzerland), July, 12^th-16^th, 2008. (P)

36)  C. Mucignat, G. Pignataro, O. Cuomo, L. Annunziato, A. Caretta. “Modulation of protein kinase A regulatory subunits distribution after transient brain ischemia”, FENS, Federation of European Neuroscience Societies, Geneve (Switzerland), July, 12^th-16^th, 2008. (P)

37)  M. Redaelli, C. Mucignat, A. Cavaggioni, A. Caretta, P. Todesco, G. Donofrio. “Bovine herpes virus 4 as a vector for gene delivery in a rat glioma model”, FENS, Federation of European Neuroscience Societies, Geneve (Switzerland), July, 12^th-16^th, 2008. (P)

38)  C. Curti, A. Sartori, P. Burreddu, G. Casiraghi. “Vicarious silylative Mukaiyama aldol reaction: a vinylogous extension”, 11^th Belgian Organic Synthesis Symposium (BOSS XI), Ghent (Belgium), July 13^th-18^th, 2008. (P) (Atti p. 104, P78)

39)  P. Coelho, D. Santos, R. Bettini, P. Colombo, F. Sonvico, O.L. Strusi. “Development of a ranitidine controlled release gastroretentive oral dosage form”, 68^th International Congress of FIP, Basel (Switzerland), August 29^th – September 4^th, 2008. (P)

40)  P. Vicini, A. Geronikaki, M. Incerti, F. Garufi, S. Ronsisvalle, A. Panico. “Antidegenerative activity of heteroaryl-imino-4-thiazolidinones on human chondrocyte cultures stimulated by IL-1b”, XX International Symposium on Medicinal Chemistry, Vienna (Austria), August 31^st - September 4^th, 2008. (P)

41)  P. Eleftheriou, A. Hazim, P. Vicini, A. Saxena, A. Geronikaki. “Novel benzo(d)thiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/ lipoxygenase inhibitors. Estimation of structure-activity relationship”, XX^th International Symposium on Medicinal Chemistry, Vienna (Austria), August 31^st - September 4^th, 2008. (P)

42)  G. Cocconcelli, V. Zuliani, M. Fantini, C. Ghiron, M. Rivara. “A practical synthesis of 2,4(5)-heteroarylimidazoles and 2-functionalized-4(5)-arylimidazoles”, Ischia Advanced School of Organic Chemistry (IASOC) 2008, Ischia Porto (NA), September 27^th – October 2^nd, 2008. (P)

43)  M. Incerti, S. Piccioni, P. Vicini. “A One-pot PPh₃-promoted synthesis of new functionalized heterocycles derived from 2-aminobenzo[d]isothiazol-3-one”, Ischia Advanced School of Organic Chemistry (IASOC) 2008, Ischia Porto (NA), September 27^th – October 2^nd, 2008. (P)

44)  C. Balaguer-Fernandez, C. Padula, A. Femenia-Font, V. Merino, F. Marra, S. Nicoli, P. Santi, A. Lopez-Castellano. “Bioadhesive properties of sumatriptan succinate transdermal delivery systems”, VIII Spanish-Portuguese Conference on Controlled Drug Delivery, Alcalà de Henares, Madrid (Spain), October 20^th – 22^nd, 2008. (P)

45)  R. Tozzi, A.A. Romani, M.M. Morganti, P. Soliani, R. Bettini, A.F. Borghetti. “Multilayered chitosan scaffold for bile duct reconstruction”, International Congress of Pisa, Pisa (Italy), October 27^th-30^th, 2008. (P)

46)  A.R. King, A. Lodola, J.R. Clapper, M. Mor, D. Piomelli. “The role of cysteine residues on monoacylglycerol lipase activity”, Neuroscience 2008, Washington (U.S.A.), November, 15^th-19^th, 2008. (P), poster n C28

47)  J.R. Clapper, F. Vacondio, A.R. King, A. Duranti, A. Tontini, G. Tarzia, M. Mor, D. Piomelli. “Novel carbamate-based fatty-acid amide hydrolase inhibitors with enhanced stability and selectivity”, Neuroscience 2008, Washington (U.S.A.), November, 15^th-19^th, 2008. (P), poster n C26

48)  F.R. Bambico, P. Hattan, N. Katz, B. Labonte, A. Duranti, A. Tontini, M. Mor, C.-D. Walker, G. Gobbi. “Differences between direct cannabinoid agonists and FAAH inhibitors on antidepressant-like behavior and on modulation of serotonin activity”, Neuroscience 2008, Washington (U.S.A.), November, 15^th-19^th, 2008. (P), poster n EE23

49)  C. Zhu, C. Solorzano, N. Battista, A. Lodola, S. Rivara, M. Mor, R. Russo, F. Antonietti, A. Duranti, A. Tontini, S. Cuzzocrea, G. Tarzia, D. Piomelli. “Inhibitors of the lisosoma lipid amidase NAAA”, Neuroscience 2008, Washington (U.S.A.), November, 15^th-19^th, 2008. (P), poster n BB21

50)  R. Ochoa-Sanchez, G. Spadoni, M. Mor, A. Bedini, S. Rivara, M. Fraschini, G. Tarzia, G. Gobbi. “Modulation of slow wave sleep (SWS) through melatonin2 (MT2) receptors”, Neuroscience 2008, Washington (U.S.A.), November, 15^th-19^th, 2008. (P), poster  n TT10

51)  M.B. Pranzo, M. Coruzzi, R. Bettini. “Solubility and solid state characterization of albendazole polymorphs”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008, poster n R6142 (P)

52)  R. Tozzi, L. Marcelloni, R. Bettini. “Enhancement of midazolam hydrochloride solubility in binary and ternary solvent misture”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008, poster n W5153 (P)

53)  A. Cavazzoni, F. Sonvico, S. Barbieri, L. Ampollini, A. Rossi, F. Gussago, G. Colombo, P. Petronini, P. Colombo, P. Carbognani. “Cell culture studies of polysaccharide films loaded with cisplatin for the loco-regional therapy of malignant pleural mesotelioma, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008. (P)

54)  A.G. Balducci, P. Colombo, C. Cavallari, L. Rodriguez, F. Sonvico, G. Colombo, A. Rossi. “Soft agglomerates of mesalazine multiparticles for colonic delivery in pediatric patients”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008. (P)

55)  C. Parlati, A. Vitale, F. Sonvico, P. Colombo, F. Buttini. “The Development of amikacin dry powder for pulmonary administration”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008. (P)

56)  F. Bortolotti, A.G. Balducci, P. Russo, E. Hesse, P. Colombo, F. Sonvico, E. Menegatti, G. Colombo. “In vitro permeation of desmopressin across rabbit nasal mucosa from liquid nasal sprays”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008. (P)

57)  C. Parlati, H. Adi, P.M. Young, K.H. Chan, P. Colombo, D. Traini. “The role of a lipophilic adjunct to produce high respirable tobramycin powders for inhalation”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008. (P)

58)  C. Chiapponi, S. Barbieri, C. Padula, F. Sonvico, M.T. Di Bari, P. Colombo, J. Ollivier, A. Deriu, P. Santi. “Application of quasi-elastic neutron scattering to the investigation of the dynamics and release properties of single-layer transdermal films containing lidocaine”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008. (P)

59)  D.R. de Araujo, C. Padula, P. Santi. “Effect of propylene glicol and transcutol on the permeation of fentanyl and benzocaine from bioadhesive films”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008. (P)

60)  S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Santi. “Transscleral permeation of bevacizumab: effect of iontophoresis application”, 2008 AAPS Annual Meeting, Atlanta (Georgia, U.S.A.), November, 16^th-20^th, 2008. (P)

 61) L. Battistini, F. Zanardi, P. Burreddu, P. Carta, A. Sartori, G. Nicastro. “Ciclopeptidi a base RGD contenenti unità amminoproliniche: una nuova classe di potenti e versatili ligandi integrinici”, XXXII Convegno nazionale della Divisione di Chimica Organica della Società Chimica Italiana, Taormina, 26-30 Luglio 2008. (C) (Atti p. 41 O5)

62) S. Rivara, M. Mor, F. Vacondio, A. Fioni, V. Lucini, A. Bedini, P. Orlando, G. Tarzia, G. Spadoni. “Design and synthesis of metabolically protected melatonin receptor agonists”, XIX National Meeting on Medicinal Chemistry, Verona, 14-18 Settembre 2008. (P)

63) A. Tontini, A. Duranti, G. Spadoni, G. Tarzia, M. Mor, S. Rivara, J. LoVerme, D. Piomelli. “Synthesis and pharmacological characterization of URB447, a new cannabinoid receptor neutral antagonist”, XIX National Meeting on Medicinal Chemistry, Verona, 14-18 Settembre 2008. (P)

64) A.A. Romani, R. Tozzi, R. Bettini, P. Soliani, A.F. Borghetti. “Scaffold tubulari multistrato a base di chitosano per la ricostruzione della via biliare principale”, Congresso Nazionale Biomateriali, Follonica (GR), 17-19 Settembre 2008. (C)

65) F. Antonietti, A. Duranti, A. Tontini, G. Tarzia, A. Lodola, S. Rivara, M. Mor, C. Zhu, C. Solorzano, D. Piomelli. “Inibitori dell’enzima NAAA (N-acylethanolamine-hydrolizing acid amidase) come nuovi agenti antinfiammatori”, Sigma-Aldrich Young Chemists Symposium, Pesaro, 20-22 Ottobre 2008. (C)

66) S. Sanchini, A. Duranti, A. Tontini, G. Tarzia, F. Vacondio, A. Fioni, A. Lodola, S. Rivara, M. Mor, J. Clapper, D. Piomelli. “Sintesi e studi di relazione struttura-attività/stabilità di carbammati inibitori dell’enzima FAAH”, Sigma-Aldrich Young Chemists Symposium, Pesaro, 20-22 Ottobre 2008. (P)

67) A. Fioni, F. Vacondio, C. Silva, S. Rivara, M. Mor, A. Bedini, G. Spadoni, G. Tarzia. “In vitro metabolism of the melatonin MT₂-receptor selective ligand UCM765 by rat, mouse and human liver substrates”, 5^th MS Pharmaday, Verona, 27-29 Ottobre 2008. (P)

V. Invited speakers

  1) R. Bettini. “Particle and crystal engineering with supercritical fluids”, International workshop on Innovation in crystal polymorphism, Bologna (Italy), January, 31^st, February, 2^nd, 2008.

  2) S. Nicoli. “Ex-vivo methods for the evaluation of drug transport across biological barriers”, 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008.

  3) P. Colombo. “Dome Matrix Technology: release module assemblage for drug delivery systems adaptable to site and time control”, 2008 Asian Scientific Conference in Pharmaceutical Technology, Penang (Malaysia), June, 1^st-3^rd, 2008.

  4) P. Colombo. “The Pharmacy Curriculum of the University of Parma”, Conference at Aristotelis Center: Improvement of the undergraduate curriculum of the School of Pharmacy, University of Athens, Athens (Greece), June, 8^th-11^th, 2008.

  5) P. Colombo. “Dome Matrix technology for flexible oral drug delivery”, Conference at Aristotelis Center: Improvement of the undergraduate curriculum of the School of Pharmacy, University of Athens, Athens (Greece), June, 8^th-11^th, 2008.

  6) S. Rivara. “Design and structure-activity relationships of subtype selective melatonin receptor Ligands”, Melatonin Receptors: Action and Therapeutics, Snowmass Village (Colorado, USA), August, 10^th-15^th, 2008.

  7) S. Nicoli. “Trandermal delivery systems”, Socrates IP program: Skin barrier functions: Cutaneous absorption and Environmental factors, Lyon (France), October 12^th-25^th, 2008.

  8) S. Nicoli. “Nanoformulations”, Socrates IP program: Skin barrier functions: Cutaneous absorption and Environmental factors, Lyon (France), October 12^th-25^th, 2008.

  9)  R. Bettini. “Drug/cyclodextrin interaction compounds obtained by microwave drying”, 1st Romanian-South African Symposium on Cyclodextrin Inclusion Complexes INCDTIM, Cluj Napoca (Romania), October 13^th-14^th, 2008.

10) P. Santi, 3rd Symposium of the TLS Academy on “Unmet need in transdermal drug delivery”, Petersberg, Konisgwinter (Germany), October 16^th-17^th, 2008.

11) P. Colombo. “Assembling of release modules for systems capable to control time and site of drug delivery”, Teams for Tomorrow, Australasian Pharmaceutical Science Association Conference, Canberra (Australia), December, 6^th-9^th, 2008.

12)  R. Bettini. “Innovazioni nel settore delle produzioni farmaceutiche”, Convegno ISPE-Innovation in Pharmaceutical Manufacturing, Milano, 28 Febbraio 2008.

13)  M. Mor. “Qsar in drug discovery: a critical reappraisal”, Workshop in New Trends in Drug Discovery, Parma, 29 Febbraio 2008.

14) G. Tarzia, A. Duranti, A. Tontini, S. Rivara, M. Mor, D. Piomelli. “Synthesis, QSAR and pharmacological evaluation of alkylcarbamic acid biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: a novel approach to antianxiety and analgesic agents”, XIII Meeting Strutture eterocicliche nella ricerca farmaceutica, Palermo, 18-21 Maggio 2008.

15) P. Colombo. “Evoluzione da sistemi di erogazione tradizionali verso sistemi innovativi”, Innovation day on device-based drug delivery systems, Azienda Agricola Ricci Curbastro di Capriolo (BS), 21 Maggio 2008.

16) P. Colombo. “Il contributo della tecnologia farmaceutica alla preparazione di formulazioni più adeguate alla somministrazione di nuovi farmaci o alla ottimizzazione di quelli esistenti”, 48° Simposio AFI, Rimini, 11-13 Giugno 2008.

17)  A. Rossi. “Come si “inventano” i medicinali”, Rotary Club Tortona, Tortona, 13 Novembre 2008.

VI. Chairperson

  1)  G. Costantino. Workshop in New Trends in Drug Discovery, Parma, Italy, February 29^th, 2008

  2)  F. Sonvico. 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008.

  3)  P. Santi. Novel drug delivery systems, University of Salerno, Salerno (Italy), June, 3^rd, 2008.

  4)  G. CASIRAGHI. Ischia Advanced School of Organic Chemistry (IASOC 2008), Ischia Porto (Na), Italy, September 28^th -October 2^nd, 2008.

VII. Awards

  1)  R. Bettini. Nomina a membro del Committee for Training and Education (CTE) della European Federation for Pharmaceutical Sciences (EUFEPS), 31 Gennaio 2008.

  2)  R. Bettini. Incarico come esperto dell’Advisory Board della Società Pharma Education Center s.r.l. di Scandicci (FI), 25 Febbraio 2008.

  3)  A. Caretta. Valutatore Progetti di Ricerca di Rilevante Interesse Nazionale (PRIN) bando 2007, 2 progetti valutati.

  4)  R. Tozzi. Premio per il miglior poster presentato al 2^nd AItUN Annual Meeting: Toward the Development of Drug Delivery Systems, Perugia (Italy), March, 7^th-8^th, 2008.

  5)  G. Casiraghi. Membro del Comitato Editoriale della rivista Chemtracts-Organic Chemistry.

VIII. Visiting researchers

  1)  Prof. ADRIAN J. MULHOLLAND, Bristol (U.K.), Centre for Computational Chemistry, University of Bristol, February, 27^th-29^th, 2008.

  2)  Dr. Daniele Ribeiro de Araujo, Campinas (Brazil), Department of Biochemistry, State University of Campinas, January 1^st-May 15^th, 2008.

  3)  Dr. Paul M. Young, Sydney (Australia), Faculty of Pharmacy, The University of Sidney, May 3^rd-6^th, 2008.

  4)  Prof. Daniela Traini, Sydney (Australia), Faculty of Pharmacy, The University of Sidney, May 3^rd-April 5^th, 2008.

  5)  Prof. Mino Rodolfo Caira, Cape Town (South Africa), Department of Chemistry, University of Cape Town, March 10^th-12^th, 2008.

  6) Prof. José Ramon Moyano, Sevilla (Spain), Departamento de Farmacia y Tecnología Farmaceutica, Universidad de Sevilla, May 4^th-9^th, 2008.

  7)  Dr. Tiziana Riccio, Pforzheim (Germany), University of Regensburg, May 5^th-October 31^st, 2008.

  8)  Prof. Siebel Suzen, Ankara (Turkey), Univeristy of Ankara, May 20^th-23th, 2008.

  9)  Prof. Adam Zoltan David, Budapest (Hungary) Semmelweis University, Department of Pharmaceutics, June 1^st – August 31^st, 2008.

IX. Visiting students

  1)  Francesca Sansone, Dipartimento di Scienze Farmaceutiche dell’Università degli Studi di Salerno (Italy), 14-23 Gennaio 2008.

  2) Achim Ramona, Facultatea de Farmacie, Universitatea de Medicina si Farmacie “Iuliu Hatiegam”, Cluj-Napoca (Romania), March, 1^st-June, 1^st, 2008.

  3) Huynh Truc Thanh Ngoc, Lab. Pharmacie Galénique, Université Claude Bernard Lyon 1 (France), April 27^th-May 1^st, May 19^th-July 9^th, September 20^th-December 31^st, 2008.

  4) Marco Tondelli, (Università degli Studi di Perugia), 1° Aprile 2008 – 15 Febbraio 2009.

  5) Marta Casas Delgado, Departamento de Farmacia y Tecnologia Farmacéutica de la Facultad de Farmacia, Universidad de Sevilla (Spain), September 1^st – December 23^rd, 2008

X. Visiting students Program Socrates/Erasmus

  1) Senyigit Taner, Ege University (Turkey) March - July 2008.

  2)  SIMAL AGUADO Jorge, Universidad Alfonso X El Sabio’ (Madrid - España), October 2007-February 2008.

  3)  ALVAREZ LUANO Marcos, Universidad Alfonso X El Sabio’ (Madrid - España), October 2007 - February 2008.

  4)  ULINSKYTE Ausra, Kaunas University of Medicine (Lietuva), October 2007 - February 2008.

  5)  SINKEVICIUTE Daiva, Kaunas University of Medicine (Lietuva), October 2007 - February 2008.

  6)  RODRIGUEZ DONES Antonio, Universidad de Granada (España), October 2007 - June 2008.

  7)  CHAVES MOLEDO Marina, Universidad de Santiago de Compostela (España), October 2007 - June 2008.

  8)  CASANOVA SANTOS Lidia, Universidad de Santiago de Compostela (España) October 2007 - June 2008.

  9)  CASTRO FRIAS Rocio, Universidad de Granada (España), October 2007 - June 2008.

10)  MADRAZO SANCHEZ Marta, Universidad Complutense de Madrid (España), October 2007 - June 2008.

11)   LOPEZ CASTILLO Carmen, Universidad Complutense de Madrid (España), October 2007 - June 2008.

12)   RAMIREZ HERRERA Ana, Universidad de Sevilla (España), October 2007 - June 2008.

13)   DEL CORRAL ALCARAZ Alicia, Universidad de Sevilla (España), October 2007 - June 2008.

14)   JUBIN GARCIA Naiara, Universidad de Navarra (España), October 2007 - June 2008.

15)   TABERNA Alejandra, Universidad de Navarra (España), October 2007 - June 2008.

16)   CHICO VICENTE Lucia, Universidad de Salamanca (España), October 2007 - February 2008.

XI. Teacher's mobility Program Socrates/Erasmus

XII. Patents

  1)  Casiraghi, C. Scolastico, F. Zanardi, L. Battistini, C. Curti, G. Rassu, L. Auzzas, P. Burreddu, L. P. Manzoni. “Integrin targeted cyclopeptide ligands, their preparation and use”, brevetto PCT Appl., N° PCT/IB2008/000366 del 19/02/2008.

  2) P. Colombo, D. Traini, P. Young, F. Buttini, C. Parlati. “A drug powder for inhalation administration and a process thereof”,  brevetto PCT/EP2008/059110 del 11/07/2008.