Description and purpose
This project aims to develop antiherpetic strategies using CpHV-1 infection in goats as a surrogate model for HHV-2. Given the limitations of current treatments and small animal models, CpHV-1 offers a biologically relevant alternative. A BoHV-4-based recombinant vaccine will be tested for efficacy and immunogenicity, with additional focus on the role of oxidative stress in herpesvirus infection.
Purpose
Demonstrating vaccine-induced immunity in the goat model will be a critical milestone toward establishing immunological correlates of protection, thereby accelerating the rational design and clinical translation of HHV-2 vaccines.
Expected results
Generation of new reagents and knowledge to combat sexually transmitted diseases.
Achieved results
A recombinant BoHV-4 expressing Caprine Herpesvirus glycoprotein D have been generated, as well as a diagnostic method to detect Caprine herpesvirus infection.
